Signalling endosomes
Description
The ability of neurons to work as individual units, regardless of their extremely polarised and complex morphology, is a consequence of the tightly regulated communication between their different domains. I am interested in the neurotrophic signalling initiated at the axon terminal and retrogradely propagated towards the soma, where it regulates survival, functional identity and neuronal morphology, and it has been proven to be crucial in the pathogenesis of several neurological diseases.
This project aims to understand how specific GTPases of the Rab family allow a mutual regulation between signalling and endosomal trafficking of TrkB receptors. More specifically, how TrkB signalling pathways regulate Rab10 for coordinating the assembly and sorting of signalling endosomes to retrograde axonal transport.
Where
The Molecular NeuroPathoBiology Lab, UCL Institute of Neurology